About us
We are a motivated and enthusiastic group of scientists working on rare diseases. The long term goal of our research group is to identify and characterize novel genes that underlie development, function and pathologies of the nervous system. We apply next generation sequencing technology to prioritize potentially causative variants in undiagnosed neurodevelopmental disorders. For functional validation of prioritized variants we undertake a multidisciplinary approach and aim to harness our discoveries for genetic diagnoses and development of efficient and personalized therapeutic strategies.
Rare diseases
Aphorism “when you hear hoofbeats behind you, don’t think zebras” is often used to train students of medicine to exclude rare and exotic diagnoses when seeing their patients. For exactly this reason, the zebra became a symbol for rare diseases. There are more than 7000 different known rare disorders, collectively affecting approximately 350 million people worldwide, and 35 million in Europe alone.
Our logo design is a colorful zebra patterned human brain to represent different rare diseases of the nervous system, each unique and rare, as are all rare disease patients.
Careers
We are always interested in motivated and enthusiastic scientists to join our team! If you don't see the position you are interested in listed below, please contact us by clicking the button on the right.
Full-time PhD position
We are seeking a curious, independent and hard working individual with interest in neurology, genetics, and intellectual disabilities to join our team. Strong background in molecular and cellular neuroscience is a plus. We recruit through the Ce-M-M- PhD Program, for more information, please click the button on the right.
Upcoming events
Sept. 28-29 2021
17th ANA Austrian Neuroscience Association Meeting in Salzburg, Austria
Meet us at the ANA Meeting in Salzburg this year! We are very excited to see our colleagues in person again, hear some great talks and contribute to this fun event!
Vanja will give a plenary talk Wed. 29th of Sept at 18:00 titled "Deciphering the 'sulfation code' of the brain extracellular matrix"
and don't miss ...
Swaroop's poster titled "Modeling rare neurodevelopmental disorders using human iPSC-derived neurons"
-and-
Sophie's poster titled "Dipeptide repeat protein toxicity and its contribution to DNA damage, nucleolar stress and heterochromatin dysregulation in ALS patients with underlying C9orf72 repeat expansions"
Registration deadline is open until July 17th. For more information go to https://www.austrian-neuroscience.at/.
Oct. 7-8 2021
Nagy Group Annual Lab Retreat
Once again our group will be celebrating the successes and challenges of the past year in a activities filled retreat at Prein, Austria. This year the group also celebrates its 5th birthday! Therefore the theme of the retreat is career building, "Where do you want to be in 5 years, and how will you make sure to get there?".
Oct. 29-30 2021
Turkish Society of Medical Biology and Genetics 17th Congress
Vanja will be presenting our work titled "Using forward and reverse genetics to understand molecular and cellular pathologies in neurodevelopmental disorders" at the biannual meeting of the Turkish Society of Medical Biology and Genetics Congress to take place online. For more information and how to register please check out https://tbgk2021.org/en/page/invitation .
Nov. 11 2021 at 11:00 am
Invited talk:
Medical University of Vienna; Centre of Physiology & Pharmacology; Institute of Pharmacology
Vanja will be presenting our work on characterizing novel neurodevelopmental disorders using genetic mouse and fly models as well as human stem cells.
Nov. 08-16 2021
Society for Neuroscience Conference, Chicago, IL, USA
Visit Chris' poster "Fibcd1 is a conserved receptor for CS-4S of the brain's extracellular matrix" and find out more about this exciting project. Virtual: November 8-11, In-Person: November 13-16, Chicago, IL --> date and time information TBA!
News and announcements
23 Sept. 2021
We were excited to join our colleagues from the Medical University of Vienna to support Michael Craig Gradwell on his 2,800 km bike ride to raise awareness for the rare disease ALS and to raise financial support for ALS research. Read all about his journey on his facebook page: https://www.facebook.com/Michaelcraiggr
We wish him luck and good health!!
11 Sept. 2021
We are proud to announce our first preprint in bioRxiv! A collaborative effort spearheaded by Chris Fell and Astrid Hagelkruys from the J. Penninger group describing a novel role of the chitin receptor FIBCD1 in neuronal function and pathophysiology of a rare neurodevelopmental disorder. The link to the paper on the right! Check it out and let us know what you think!
14 June 2021
Another really fun lab outing just to celebrate the privilege of getting vaccinated, the beauty of the summer heat, and reopening of public spaces and restaurants in Vienna! We started with Indiana Jones-themed escape room and topped it off with a nice outdoor restaurant that ended in high speed scooter rides through the Vienna center!
10 May 2021
We are thrilled to have been accepted as members to the Undiagnosed Diseases Network International (UDNI)! We look forward to participating in and contributing to this excellent organization!
14 April 2021
Congratulations to our postdoc Dr. Swaroop Achuta for being one of the finalists for the 3Brain Massimo Grattarola Award for innovative ideas in technological advancement in neuroscience research!
22 March 2021
The Nagy team welcomes its first MD undergraduate student, Haluk Caliskan, who will as part of his thesis project work on whole-exome sequencing and genetics analysis of undiagnosed neurodevelopmental cases. Welcome Haluk!
14-16 April 2021
Chris Fell will be presenting his work on a novel lectin receptor and its role in neural development and function in poster and lightning talk format at the Genomics of Brain Disorders Virtual Conference.
15-16 March 2021
The first European Syngap1 and Related Neurodevelopmental Disorders Symposium was a smashing success! We heard talks from a combination of renown neuroscientists, top notch clinicians, patient organizations and parents with affected children. We are grateful to our fellow organizers and admins' support, and especially thankful to the patient organization group Leon&Friends for making all of this happen. Special thanks to Chris Fell for his superb IT skills during the conference. Looking forward to next year!
Get to know this wonderful and active patient advocacy organization Leon&Friends by visiting their website by clicking their logo.
12 March 2021
During times of lockdowns, quarantines, social distancing and shift work it is harder than even to keep your research group motivated and team oriented. CellMentor discusses some fun ideas for the virtual lab meeting, mentioning some of our ideas as well!
18-19th March 2021
Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases welcomes its Scientific Advisory Board. This year in online format, we are looking forward to interacting with the board members and showcasing our recent accomplishments.
28 Feb. 2021
February 28th is rare disease day. Due to COVID restrictions worldwide efforts to raise awareness of rare diseases and fundraiser activities will, unfortunately, be challenging. Check out the official Rare Disease Day page to learn how you can get involved and contribute.
18 Feb. 2021
14:00-17:00 Edenhofer/Nagy Gene Editing in Neural Cells Workshop
Workshop is organized to foster collaboration and communication between the two research groups with a common interest in genome editing screens in neurons.
25 Feb. 2021
Nagy lab outing! The weather is finally warming up, Spring is almost here, its time to be outside! There are not many opportunities to spend time together during COVID quarantines, so we are off to a peri-Vienna hike.
March 2021
March issue of the journal Trends in Molecular Medicine not only includes Chris' Opinion article "Cellular Models and High-Throughput Screening for Genetic Causality of Intellectual Disability" but also highlights Vanja's scientific journey as part of their Stories in Molecular Medicine segment. Our unbiased opinion is that this is definitely the issue to check out!
12. Feb. 2021
There are more than 7000 different rare diseases, most without any treatments. Amazingly, for a metabolic disorder erythropoietic protoporphyria (OMIM# 177000), marked by light sensitivity and extreme pain, there is an EMA approved treatment, Afamelanotide, which has been shown to allow people with this condition to live a nearly normal, pain-free life! Shockingly, in Austria, Afamelanotide is only available to 5 people (?!) Luckily, you can do something about this. Make your voice heard and help people with this rare and difficult condition see the light of day (literally!!) Simply, sign the petition! Its the least you can do for rare disease month.
02 Jan. 2021
PhD Student Christopher Fell's Opinion article titled "Cellular Models and High-Throughput Screening for Genetic Causality of Intellectual Disability" is online at Trends in Molecular Medicine! Congrats Chris!
Link: https://www.sciencedirect.com/science/article/pii/S1471491420303166
01 Nov. 2020
New postdoctoral fellow, Dr. Swaroop Achuta joins the lab. Welcome Swaroop!
08 Aug. 2020
PhD Students Sophie Imhof and Dr. Tomislav Kokotovic's forum article titled "PRDM12: New Opportunity in Pain Research" published in Trends in Molecular Medicine! congrats Sophie and Tomislav!
Link: https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30186-6
03 Aug. 2020
The Nagy team is awarded the FWF 1000s Ideas Programme grant for their work titled:"Reverse Engineering of Neurodevelopmental Disorders". The grant was co-authored by PhD Student Christopher Fell and will be spearheaded by PhD student Victoria Kartysh.
Read more:
01 Aug. 2020
New PhD student Victoria Kartysh joins the lab. Welcome Victoria!
