Fell, CW.*, Hagelkruys, A.*… J. Penninger#, Nagy, V#. FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder. EMBO Mol Med, 2022. e15829. (Highlighted on the cover of the September 2022 issue)

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Kokotović, T.*, Lenartowicz, E.*, Langeslag, M., Ciotu, C.I., Fell, C.W., Scaramuzza, A., Fischer, M.J.M., Kress, M., Penninger, J.M., and Nagy, V. Transcription factor Mesenchyme Homeobox Protein 2 (MEOX2) modulates nociceptor function. The FEBS Journal, 289(2022) 3457–3476. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.16347

 

Case Report: Alehabib, E., Kokotović, T., Ranji-Burachaloo, S., Tafakhori, A., Molaei Ramsheh, S., Esmaeilizadeh, Z., Darvish, H., Movafagh, A.# , Nagy, V. # Leu226Trp CACNA1A variant associated with juvenile myoclonic epilepsy with and without intellectual disability. Clinical Neurology and Neurosurgery. 2022 February, 213: 107108 https://www.sciencedirect.com/science/article/abs/pii/S0303846721006375?via%3Dihub

 

Vulliard, L., Hancock, J., Kamnev, A., Fell, CW., Ferreira da Silva, J., Loizou, J., Nagy, V., Dupré, L., Menche, J. BioProfiling.jl: Profiling biological perturbations with high-content imaging in single cells and heterogeneous populations. Bioinformatics. 2021 Dec 22;btab853. https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btab853/6478274

 

Buphamalai, P., Kokotović, T., Nagy, V., Menche, J., Network analysis reveals rare disease signatures across multiple levels of biological organization; Nature Comms. 2021. Nov. 09; 12, Article number: 6306. https://www.nature.com/articles/s41467-021-26674-1

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Case Report: Freyberger, F., Kokotović, T., Krnjak, G, Huljev Frković, S., and Nagy, V. Expanding the known phenotype in Mullegama-Klein-Martinez syndrome in male patients. Human Genome Variation. 8, Article number: 37 (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8476567/

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Kokotović, T., Langeslag, M., Lenartowicz, E., Manion, J., Fell, CW., Alehabib, E., Tafakhori, A., Darvish, H., Bellefroid, CW., Neely, GG., Kress, M., Penninger, JM., and Nagy, V. PRDM12 is transcriptionally active and required for nociceptor function throughout life. Front Mol Neurosci. 2021. Sept. 27; In press. https://doi.org/10.3389/fnmol.2021.720973. 

 

Fell, CW., Hagelkruys, A., Cicvaric, A., Horrer, M., Liu, L., Shing, J., Li, JSS, Stadlmann, J., Polyansky, AA., Mereiter, S., Miguel Tejada, MA.,  Kokotovic, T., Scaramuzza, A., Twyman, K., Morrow, MM., Juusola, J., Yan, H., Wang, JMBD.,  Burmeister, M.,  Andersen, TL., Wirnsberger, G., Holmskov, U., Perrimon, N., Zagrovic, B., Monje, FJ., Moeller, JB.,Penninger, JM., and Nagy, V. FIBCD1 is a Conserved Receptor for Chondroitin Sulphate Proteoglycans of the Brain Extracellular Matrix and a Candidate Gene for a Complex Neurodevelopmental Disorder. bioRxiv. https://www.biorxiv.org/content/10.1101/2021.09.09.459581v1

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Fell, C. and Nagy, V. Cellular Models and High-throughput Screening for Genetic Causality of Intellectual Disability. Trends in Molecular Medicine. In press. Jan 2021. https://doi.org/10.1016/j.molmed.2020.12.003.

 

Imhof, S., Kokotovic, T., and Nagy, V. PRDM12: New Opportunity of Pain Research.Trends in Molecular Medicine. 2020 Oct.01; 26(10):895-897. https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30186-6 

 

Orthofer, M1,†, Valsesia, A2,†, … Nagy, V12, G. Neely, GG6,7, Esterbauer, H5, Haubensak, W4, Metspalu, A3, Hager, J2,*, Gheldof, N2,*, Penninger, JP1,*. Identification of ALK in thinness. Cell. 2020 Jun 11;181(6):1246-1262.e22. https://pubmed.ncbi.nlm.nih.gov/32442405/

 

Desiderio, S*., Vermeiren, S*., Van Campenhout, C., Kricha, S., Malki, E., Fletcher, V.E., Vanwelden, T., Schmidt, B.Z., Henningfeld, K. A., Pieler, T., Woods, C.G., Nagy, V#.,Verfaillie, C#., and Bellefroid, E. J#., Prdm12 directs nociceptive sensory neuron development by regulating the expression of the NGF receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5. https://www.cell.com/cell-reports/supplemental/S2211-1247(19)30283-9

 

Nagy, V#., et al., HACE1 deficiency leads to structural and functional neurodevelopmental defects. NeurolGenet. 2019; 5(3). https://ng.neurology.org/content/5/3/e330

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Lee, N., Clarke, I., Zengin, A., Enriquez, R., Nagy, V., et al., RANK deletion in neuropeptide Y neurones attenuates oestrogen deficiency-related bone loss. J Neuroendocrinol. 2019 Feb;31(2):e12687. doi: 10.1111/jne.12687. Epub 2019 Feb 1. https://pubmed.ncbi.nlm.nih.gov/30633834/

 

Lee, N., Clarke, I., Enriquez, R., Nagy, V., et al., Central RANK signaling in NPY neurons alters bone mass in male mice. Neuropeptides. 2018 Apr;68:75-83. Epub 2018 Feb 15. https://pubmed.ncbi.nlm.nih.gov/29477253/

 

Nagy, V.*, Cole, T.*, Van Campenhout, C.*, Khoung, TM*., et al., The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle.  2015, 14(12):1799-808.  https://pubmed.ncbi.nlm.nih.gov/25891934/

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Nagy, V., and Penninger, JM., The RANKL-RANK story. Gerontology. 2015, 61(6):534-42. https://pubmed.ncbi.nlm.nih.gov/25720990/

 

Ikeda, F., Deribe, YL., Skånland, SS., Stieglitz, B., Grabbe, C., Franz-Wachtel, M., vanWijk, SJ., Goswami, P., Nagy, V., et al., SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature. 2011, Mar 31; 471(7340):637-41. https://pubmed.ncbi.nlm.nih.gov/21455181/

 

Nagy, V. and Dikic, I. Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity. Biological Chemistry. 2010, Feb-Mar; 391(2-3):163-9. https://pubmed.ncbi.nlm.nih.gov/21455181/

 

Bekirov, IH., Nagy, V., Svoronos, A., Huntley, GW., Benson, DL. Cadherin-8 and N- Cadherin differentially regulate pre- and postsynaptic development of the hippocampal mossy fiber pathway. Hippocampus. 2008,18(4):349-63. https://pubmed.ncbi.nlm.nih.gov/18064706/

 

Nagy, V., Bozdagi, O., and Huntley GW.  Extracellular protease matrix metalloprotease-9 is activated by inhibitory avoidance memory and required for long-term memory., LearnMem. 2007, Sep 25; 14(10):655-64. https://pubmed.ncbi.nlm.nih.gov/17909100/

 

Bozdagi, O., Nagy, V., Kwei, K., and Huntley GW.  In vivo roles for matrixmetalloprotease-9 in mature hippocampal synaptic physiology and plasticity.  J Neurophysiol. 2007, Jul;98(1):334-44. https://pubmed.ncbi.nlm.nih.gov/17493927/

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Nagy, V.,* Bozdagi, 0* et al., Matrix Metalloproteinase-9 Is Required for Hippocampal Late- Phase Long-Term Potentiation and Memory. J Neurosci., 2006, 26(7):1923-1934. https://pubmed.ncbi.nlm.nih.gov/16481424/

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Marambaud, P., Shioi, J., Serban, G., Georgakopoulos, A., Sarner, S., Nagy, V., et al., A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 2002, Apr 15;21(8):1948-56. https://pubmed.ncbi.nlm.nih.gov/11953314/ 

 

Gomes, I., Jordan, BA., Gupta, A., Trapaidze, N., Nagy, V., Devi, LA. Heterodimerization of mu and delta opioid receptors: A role in opiate synergy. J Neurosci. 2000, Nov 15;20(22). https://pubmed.ncbi.nlm.nih.gov/11069979/

 

Petanceska, SS., Nagy, V., Frail, D., Gandy, S.  Ovariectomy and 17beta-estradiolmodulate the levels of Alzheimer's amyloid beta peptides in brain. Neurology. 2000, Jun27;54(12):2212-7. https://pubmed.ncbi.nlm.nih.gov/10881241/

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* contributed equally

# jointly directed the work